A compendium of natural philosophical knowledge, written in 1718-1720 by John Questebrune, chaplain to the 6th Earl of Galway. The chapters treat the various parts of the physical world (earth, water, air, and fire), plants (including a great deal on medicinal plants), animals, and the human body and soul. The volume is embellished with decorative chapter headings and pen and ink and watercolor sketches depicting the terrestrial globe, the Ptolemaic and Copernican solar systems, the phases of the moon, and the human body in dissection.

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.